Selecta Biotech SE · Bratislava

Oligonucleotide therapy, reimagined.

Excellence-driven commitment to your health. A new generation of tailor-made oligonucleotide therapeutics built on our patented ESiNAR-X® platform – exclusive therapeutic intervention against molecular targets, without treatment-induced toxicity.

Best MedTech Innovation of the Year 2022 — European Union
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Our commitment

We strive to bring safe and reliable treatment modalities to patients with unmet medical need – transforming the promise of modern science.

Selecta Biotech SE is a European joint-stock company founded to improve patient health care through the development of safe, next-generation oligonucleotide therapeutics. Built on innovative science, the company is working to bring highly selective therapies into clinical practice with the goal of maximizing therapeutic benefit while minimizing treatment-related toxicity.

We collaborate with regional partners to establish a biotechnological ecosystem supporting interdisciplinary biomedical research.

More about us
Therapeutic areas on one platform
Therapeutic leads advancing to the clinic
Years of research in oligonucleotide science
Patented platform
(ESiNAR-X®)
Technology · ESiNAR-X®

Treating disease where it begins.

Unlike conventional therapeutics, oligonucleotides recognise and bind to messenger RNA. By promoting its degradation or preventing further processing, they stop disease-causing proteins from being produced in the first place.

Exceptional specificity

Recognises exclusively the target RNA – does not interfere with homologous RNA off-targets.

Unprecedented safety

Preclinical studies show excellent tolerability and no treatment-induced toxicity.

High versatility

Fully adaptable to different target RNAs – one modular platform, many programs.

Mechanism of action
ESiNAR-X®Reduce target RNA levels to as low as 0%
Therapeutics

A single platform, five therapeutic areas.

A single technology platform powers a growing pipeline of therapeutic candidates targeting diseases with significant unmet medical need.

Why ESiNAR-X® is different

Designed around the limitations of today's oligonucleotides.

Inherent constraints

Conventional oligonucleotides

  • Drug promiscuity drives clinically relevant side effects
  • Poor cellular uptake demands frequent, larger doses
  • Limited efficacy and non-selective therapeutic action
The ESiNAR-X® approach

On target by design

  • Exclusive selectivity – biologic effect only in target cells
  • Spontaneous cellular uptake – less frequent, smaller doses
  • Remarkable efficacy – reduce target RNA levels to as low as 0%
Recognition & collaboration

Validated by peers, trusted by partners.

Our scientific advances are supported by collaborations with leading European research institutions and organizations, driving the development of innovative oligonucleotide therapeutics.

2023

Best innovation in medical technology

Innovation & Excellence Awards.

2022

Best MedTech innovation of the year – EU

Research & Development Awards.

2022

Young biotechnology company of the year

Innovation & Excellence Awards.

All awards & certificates
Partners

In collaboration with leading institutions.

Through collaborations with hospitals, research institutes, and academic partners across Slovakia and Europe, we translate scientific discoveries into differentiated therapeutic solutions.

Univerzitná nemocnica Bratislava Ústav hematologie a krevní transfuze Slovenská akadémia vied Národný onkologický ústav MediScine
With the support of Ministry of Economy of the Slovak Republic

This project was supported under the Recovery and Resilience Plan of the Slovak Republic · Innovation voucher no. 09I02-03-V03-00366.

Newsroom

A view from the frontier.

All news
Milestone10 Dec 2025

From Vision to Trials: seven years of bold science

One mission taking shape: turning pioneering oligonucleotide science into therapeutic candidates with the potential to reach patients.

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Events24 Nov 2025

MEDICA 2025 Reflections: where innovation meets purpose

Reflections from Düsseldorf, where encounters with clinicians, innovators and partners brought new perspective, pride and renewed belief in what our science can make possible for patients.

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Perspective23 Oct 2025

Reflections on the OTS Annual Meeting 2025

Notes from the Oligonucleotide Therapeutics Society – a field in motion, and a community increasingly connected by the possibilities ahead.

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Contact us

Ready to explore the opportunity?

Whether you are an investor, research partner, or future colleague, we would be glad to hear from you. We welcome conversations with people who share our interest in advancing oligonucleotide therapeutics and developing safer medicines.